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Trimethyl Orthoformate

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Product Description
Physical and Chemical Properties:
Physical state and Appearance : Colorless liquid
Odor : Pungent. Aromatic, ester-like
Molecular Weight : 106.12 g/mole
Color : Colorless. Clear
Boiling Point : 100.6°C (213.1°F)
Melting Point : -53°C (-63.4°F)
Specific Gravity : 0.9676 (Water = 1)
Vapor Density : 3.67 (Air = 1)
Solubility : Soluble in diethyl ether. Soluble in Ethanol. Hydrolyzes in water.
Purity % : 99 min
Methanol % : 0.4
Methyl Formate % : 0.2


Trimethyl Orthoformate (TMOF) mainly as organic intermediates for:

  •         Pharmaceutical,
  •         Agrochemical
  •         Spices Synthesis,
  •         A coating agent.


Trimethyl orthoformate is a the simplest orthoester. It is a reagent used in organic synthesis for the introduction of a protecting group for aldehydes. The product of reaction of an aldehyde with trimethyl orthoformate is an acetal. In general cases, these acetals can be deprotected back to the aldehyde by using hydrochloric acid.


  • Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed and sealed until ready for use. Avoid all possible sources of ignition (spark or flame). Moisture sensitive.
  • Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do not breathe gas/fumes/ vapor/spray. Avoid contact with eyes. Wear suitable protective clothing. If ingested, seek medical advice immediately and show the container or the label. Keep away from incompatibles such as oxidizing agents, combustible materials, acids.

Product Code : 01

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